1flo

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{{STRUCTURE_1flo| PDB=1flo | SCENE= }}
{{STRUCTURE_1flo| PDB=1flo | SCENE= }}
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'''FLP RECOMBINASE-HOLLIDAY JUNCTION COMPLEX I'''
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===FLP RECOMBINASE-HOLLIDAY JUNCTION COMPLEX I===
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==Overview==
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The crystal structure of a Flp recombinase tetramer bound to a Holliday junction intermediate has been determined at 2.65 A resolution. Only one of Flp's two domains, containing the active site, is structurally related to other lambda integrase family site-specific recombinases, such as Cre. The Flp active site differs, however, in that the helix containing the nucleophilic tyrosine is domain swapped, such that it cuts its DNA target in trans. The Flp tetramer displays pseudo four-fold symmetry matching that of the square planar Holliday junction substrate. This tetramer is stabilized by additional novel trans interactions among monomers. The structure illustrates how mechanistic unity is maintained on a chemical level while allowing for substantial variation on the structural level within a family of enzymes.
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{{ABSTRACT_PUBMED_11090626}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Tyrosine recombinase]]
[[Category: Tyrosine recombinase]]
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Revision as of 00:27, 1 July 2008

Image:1flo.png

Template:STRUCTURE 1flo

FLP RECOMBINASE-HOLLIDAY JUNCTION COMPLEX I

Template:ABSTRACT PUBMED 11090626

About this Structure

1FLO is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping., Chen Y, Narendra U, Iype LE, Cox MM, Rice PA, Mol Cell. 2000 Oct;6(4):885-97. PMID:11090626

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