1fmv

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{{STRUCTURE_1fmv| PDB=1fmv | SCENE= }}
{{STRUCTURE_1fmv| PDB=1fmv | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE APO MOTOR DOMAIN OF DICTYOSTELLIUM MYOSIN II'''
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===CRYSTAL STRUCTURE OF THE APO MOTOR DOMAIN OF DICTYOSTELLIUM MYOSIN II===
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==Overview==
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Myosin is the most comprehensively studied molecular motor that converts energy from the hydrolysis of MgATP into directed movement. Its motile cycle consists of a sequential series of interactions between myosin, actin, MgATP, and the products of hydrolysis, where the affinity of myosin for actin is modulated by the nature of the nucleotide bound in the active site. The first step in the contractile cycle occurs when ATP binds to actomyosin and releases myosin from the complex. We report here the structure of the motor domain of Dictyostelium discoideum myosin II both in its nucleotide-free state and complexed with MgATP. The structure with MgATP was obtained by soaking the crystals in substrate. These structures reveal that both the apo form and the MgATP complex are very similar to those previously seen with MgATPgammaS and MgAMP-PNP. Moreover, these structures are similar to that of chicken skeletal myosin subfragment-1. The crystallized protein is enzymatically active in solution, indicating that the conformation of myosin observed in chicken skeletal myosin subfragment-1 is unable to hydrolyze ATP and most likely represents the pre-hydrolysis structure for the myosin head that occurs after release from actin.
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(as it appears on PubMed at http://www.pubmed.gov), where 10954715 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10954715}}
==About this Structure==
==About this Structure==
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[[Category: Thoden, J B.]]
[[Category: Thoden, J B.]]
[[Category: Myosin motor domain]]
[[Category: Myosin motor domain]]
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Revision as of 00:32, 1 July 2008

Image:1fmv.png

Template:STRUCTURE 1fmv

CRYSTAL STRUCTURE OF THE APO MOTOR DOMAIN OF DICTYOSTELLIUM MYOSIN II

Template:ABSTRACT PUBMED 10954715

About this Structure

1FMV is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain., Bauer CB, Holden HM, Thoden JB, Smith R, Rayment I, J Biol Chem. 2000 Dec 8;275(49):38494-9. PMID:10954715

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