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1fna

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{{STRUCTURE_1fna| PDB=1fna | SCENE= }}
{{STRUCTURE_1fna| PDB=1fna | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE TENTH TYPE III CELL ADHESION MODULE OF HUMAN FIBRONECTIN'''
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===CRYSTAL STRUCTURE OF THE TENTH TYPE III CELL ADHESION MODULE OF HUMAN FIBRONECTIN===
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==Overview==
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The crystal structure of the cell adhesion module of fibronectin (FNIII10) has been determined at 1.8 A resolution. A recombinant fragment corresponding to the tenth type III module of human fibronectin was crystallized in space group P2(1) with a = 30.7, b = 35.1 and c = 37.7 A and beta = 107 degrees. The structure was determined by molecular replacement and refined by least squares methods. The crystallographic R-factor for the final model of the 91 amino acid module plus 56 solvent atoms is 0.18 for 10 to 1.8 A data. The module consists of two layers of beta-sheet, one with three antiparallel strands and the other with four antiparallel strands. The beta-sheets enclose a hydrophobic core of 24 amino acid side-chains. The module contains the RGD cell recognition sequence in a flexible loop connecting two beta-strands. The tertiary structure of the FNIII10 module has been used to develop a structure-based sequence alignment of 17 type III modules in fibronectin based on the striking conservation of homologous hydrophobic residues. A similar pattern of homologous alternating hydrophobic residues is also evident in a comparison of type III modules in proteins unrelated to fibronectin such as cytokine receptors and muscle proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 8120888 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8120888}}
==About this Structure==
==About this Structure==
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[[Category: Veerapandian, B.]]
[[Category: Veerapandian, B.]]
[[Category: Cell adhesion protein]]
[[Category: Cell adhesion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:31:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:36:29 2008''

Revision as of 00:36, 1 July 2008

Image:1fna.png

Template:STRUCTURE 1fna

CRYSTAL STRUCTURE OF THE TENTH TYPE III CELL ADHESION MODULE OF HUMAN FIBRONECTIN

Template:ABSTRACT PUBMED 8120888

About this Structure

1FNA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tenth type III cell adhesion module of human fibronectin., Dickinson CD, Veerapandian B, Dai XP, Hamlin RC, Xuong NH, Ruoslahti E, Ely KR, J Mol Biol. 1994 Mar 4;236(4):1079-92. PMID:8120888

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