1fnn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fnn.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fnn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fnn| PDB=1fnn | SCENE= }}
{{STRUCTURE_1fnn| PDB=1fnn | SCENE= }}
-
'''CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM'''
+
===CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM===
-
==Overview==
+
<!--
-
Cdc6/Cdc18 is a conserved and essential component of prereplication complexes. The 2.0 A crystal structure of an archaeal Cdc6 ortholog, in conjunction with a mutational analysis of the homologous Cdc18 protein from Schizosaccharomyces pombe, reveals novel aspects of Cdc6/Cdc18 function. Two domains of Cdc6 form an AAA+-type nucleotide binding fold that is observed bound to Mg.ADP. A third domain adopts a winged-helix fold similar to known DNA binding modules. Sequence comparisons show that the winged-helix domain is conserved in Orc1, and mutagenesis data demonstrate that this region of Cdc6/Cdc18 is required for function in vivo. Additional mutational analyses suggest that nucleotide binding and/or hydrolysis by Cdc6/Cdc18 is required not only for progression through S phase, but also for maintenance of checkpoint control during S phase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11030343}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11030343 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11030343}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Dna replication initation factor]]
[[Category: Dna replication initation factor]]
[[Category: Orc1]]
[[Category: Orc1]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:32:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:37:51 2008''

Revision as of 00:37, 1 July 2008

Image:1fnn.png

Template:STRUCTURE 1fnn

CRYSTAL STRUCTURE OF CDC6P FROM PYROBACULUM AEROPHILUM

Template:ABSTRACT PUBMED 11030343

About this Structure

1FNN is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control., Liu J, Smith CL, DeRyckere D, DeAngelis K, Martin GS, Berger JM, Mol Cell. 2000 Sep;6(3):637-48. PMID:11030343

Page seeded by OCA on Tue Jul 1 03:37:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fnn"
Personal tools