1fod

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[[Image:1fod.gif|left|200px]]
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{{Seed}}
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[[Image:1fod.png|left|200px]]
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{{STRUCTURE_1fod| PDB=1fod | SCENE= }}
{{STRUCTURE_1fod| PDB=1fod | SCENE= }}
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'''STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS'''
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===STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS===
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==Overview==
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Attachment of foot-and-mouth disease virus (FMDV) to its cellular receptor involves a long and highly antigenic loop containing the conserved sequence, Arg-Gly-Asp, a motif known to be a recognition element in many integrin-dependent cell adhesion processes. In our original crystal structure of FMDV the Arg-Gly-Asp-containing loop ('the loop'), located between beta-strands G and H of capsid protein VP1, was disordered and hence essentially invisible. We previously surmised that its disorder is enhanced by a disulphide bond linking the base of the loop (Cys 134) to Cys 130 of VP2 (ref. 8). We report here the crystal structure of the virus in which this disulphide is reduced. Reduced virus retains infectivity and serological experiments suggest that some of the loop's internal structure is conserved. But here its structure has become sufficiently ordered to allow us to describe an unambiguous conformation, which we relate to some key biological properties of the virus.
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The line below this paragraph, {{ABSTRACT_PUBMED_8385272}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8385272 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8385272}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:34:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:40:42 2008''

Revision as of 00:40, 1 July 2008

Image:1fod.png

Template:STRUCTURE 1fod

STRUCTURE OF A MAJOR IMMUNOGENIC SITE ON FOOT-AND-MOUTH DISEASE VIRUS

Template:ABSTRACT PUBMED 8385272

About this Structure

1FOD is a Protein complex structure of sequences from Foot-and-mouth disease virus. Full crystallographic information is available from OCA.

Reference

Structure of a major immunogenic site on foot-and-mouth disease virus., Logan D, Abu-Ghazaleh R, Blakemore W, Curry S, Jackson T, King A, Lea S, Lewis R, Newman J, Parry N, et al., Nature. 1993 Apr 8;362(6420):566-8. PMID:8385272

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