This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1fop

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fop.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fop.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fop| PDB=1fop | SCENE= }}
{{STRUCTURE_1fop| PDB=1fop | SCENE= }}
-
'''BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-BOUND)'''
+
===BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-BOUND)===
-
==Overview==
+
<!--
-
The crystal structure of the endothelial nitric oxide synthase (NOS) heme domain complexed with NO reveals close hydrogen bonding interactions between NO and the terminal guanidino nitrogen of the substrate, L-arginine. Dioxygen is expected to bind in a similar mode which will facilitate proton abstraction from L-Arg to dioxygen, a required step for O-O bond cleavage. Structures of mechanism-based NOS inhibitors, N(5)-(1-iminoethyl)-L-ornithine and N-(3-(aminomethyl)benzyl)acetamidine, provide clues on how this class of compounds operate as suicide substrate inhibitors leading to heme oxidation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11331003}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11331003 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11331003}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Alpha-beta fold]]
[[Category: Alpha-beta fold]]
[[Category: Nitric oxide synthase]]
[[Category: Nitric oxide synthase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:35:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:41:46 2008''

Revision as of 00:41, 1 July 2008

Image:1fop.png

Template:STRUCTURE 1fop

BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH L-ARG AND NO(H4B-BOUND)

Template:ABSTRACT PUBMED 11331003

About this Structure

1FOP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors., Li H, Raman CS, Martasek P, Masters BS, Poulos TL, Biochemistry. 2001 May 8;40(18):5399-406. PMID:11331003

Page seeded by OCA on Tue Jul 1 03:41:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fop"
Personal tools