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1fos

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[[Image:1fos.gif|left|200px]]
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{{Seed}}
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[[Image:1fos.png|left|200px]]
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{{STRUCTURE_1fos| PDB=1fos | SCENE= }}
{{STRUCTURE_1fos| PDB=1fos | SCENE= }}
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'''TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES'''
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===TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES===
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==Overview==
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The Fos and Jun families of eukaryotic transcription factors heterodimerize to form complexes capable of binding 5'-TGAGTCA-3' DNA elements. We have determined the X-ray crystal structure of a heterodimer of the bZIP regions of c-Fos and c-Jun bound to DNA. Both subunits form continuous alpha-helices. The carboxy-terminal regions form an asymmetric coiled-coil, and the amino-terminal regions make base-specific contacts with DNA in the major groove. Comparison of the two crystallographically distinct protein-DNA complexes show that the coiled-coil is flexibly joined to the basic regions and that the Fos-Jun heterodimer does not recognize the asymmetric 5'-TGAGTCA-3' recognition element in a unique orientation. There is an extensive network of electrostatic interactions between subunits within the coiled-coil, consistent with proposals that these interactions determine preferential formation of the heterodimer over either of the homodimers.
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The line below this paragraph, {{ABSTRACT_PUBMED_7816143}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7816143 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7816143}}
==About this Structure==
==About this Structure==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Heterodimer]]
[[Category: Heterodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:35:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:41:59 2008''

Revision as of 00:42, 1 July 2008

Image:1fos.png

Template:STRUCTURE 1fos

TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES

Template:ABSTRACT PUBMED 7816143

About this Structure

1FOS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA., Glover JN, Harrison SC, Nature. 1995 Jan 19;373(6511):257-61. PMID:7816143

Page seeded by OCA on Tue Jul 1 03:41:59 2008

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