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1fpt

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{{STRUCTURE_1fpt| PDB=1fpt | SCENE= }}
{{STRUCTURE_1fpt| PDB=1fpt | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE'''
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===THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE===
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==Overview==
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The crystal structure of the complex between the Fab fragment of C3, a neutralizing antibody for poliovirus, and a peptide corresponding to the viral epitope has been determined at 3.0 A resolution. Although this antibody was originally raised to heat inactivated (noninfectious) virus particles, it strongly neutralizes the Mahoney strain of type 1 poliovirus. Eleven peptide residues are well-defined in the electron-density map and form two type I beta-turns in series. At the carboxyl end, the peptide is bound snugly in the antibody-combining site and adopts a conformation that differs significantly from the structure of the corresponding residues in the virus. Structural comparisons between the peptide in the complex and the viral epitope suggests that on binding to infectious virions, this antibody may induce structural changes important for neutralization.
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(as it appears on PubMed at http://www.pubmed.gov), where 7539711 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7539711}}
==About this Structure==
==About this Structure==
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[[Category: Hogle, J M.]]
[[Category: Hogle, J M.]]
[[Category: Wien, M W.]]
[[Category: Wien, M W.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:37:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:45:13 2008''

Revision as of 00:45, 1 July 2008

Image:1fpt.png

Template:STRUCTURE 1fpt

THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN THE FAB FRAGMENT OF AN NEUTRALIZING ANTIBODY FOR TYPE 1 POLIOVIRUS AND ITS VIRAL EPITOPE

Template:ABSTRACT PUBMED 7539711

About this Structure

1FPT is a Protein complex structure of sequences from Human poliovirus 1 and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope., Wien MW, Filman DJ, Stura EA, Guillot S, Delpeyroux F, Crainic R, Hogle JM, Nat Struct Biol. 1995 Mar;2(3):232-43. PMID:7539711

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