1fqx

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{{STRUCTURE_1fqx| PDB=1fqx | SCENE= }}
{{STRUCTURE_1fqx| PDB=1fqx | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR'''
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===CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR===
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==Overview==
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Crystallization conditions for an HIV-1 protease-inhibitor complex were optimized to produce crystals suitable for X-ray diffraction experiments. The X-ray structure of the HIV-1 protease complex was solved and refined at 3.1 A resolution. In contrast to Saquinavir, the mimetic hydroxy group of the inhibitor Boc-Phe-Psi[(S)-CH(OH)CH(2)NH]-Phe-Glu-Phe-NH(2) is placed asymmetrically with respect to the non-crystallographic twofold axis of the protease dimer so that hydrogen bonds between the amino group of the inhibitor and the catalytic aspartates can be formed. The inhibitor binds in the centre of the active site by a compact network of hydrogen bonds to Gly27, Gly127, Asp25, Asp125 and via the buried water molecule W301 to Ile50 and Ile150.
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The line below this paragraph, {{ABSTRACT_PUBMED_11223536}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11223536 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11223536}}
==About this Structure==
==About this Structure==
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[[Category: Peptidomimetic]]
[[Category: Peptidomimetic]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:39:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:48:21 2008''

Revision as of 00:48, 1 July 2008

Image:1fqx.png

Template:STRUCTURE 1fqx

CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR

Template:ABSTRACT PUBMED 11223536

About this Structure

1FQX is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.

Reference

A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease., Dohnalek J, Hasek J, Duskova J, Petrokova H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlacek J, Fabry M, Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):472-6. PMID:11223536

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