1frt

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[[Image:1frt.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1frt| PDB=1frt | SCENE= }}
{{STRUCTURE_1frt| PDB=1frt | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC'''
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===CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC===
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==Overview==
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The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively). A low-resolution crystal structure of the complex between FcRn and Fc localizes the binding site for Fc to the side of FcRn, distinct from the tops of the alpha 1 and alpha 2 domains which serve as the peptide and T-cell receptor binding sites in class I molecules. FcRn binds to Fc at the interface between the Fc CH2 and CH3 domains, which contains several histidine residues that could account for the sharply pH-dependent FcRn/IgG interaction. A dimer of FcRn heterodimers observed in the co-crystals and in the crystals of FcRn alone could be involved in binding Fc, correlating with the 2:1 binding stoichiometry between FcRn and IgG (ref. 4) and suggesting an unusual orientation of FcRn on the membrane.
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The line below this paragraph, {{ABSTRACT_PUBMED_7969498}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7969498 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7969498}}
==About this Structure==
==About this Structure==
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[[Category: Bjorkman, P J.]]
[[Category: Bjorkman, P J.]]
[[Category: Burmeister, W P.]]
[[Category: Burmeister, W P.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:41:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:50:55 2008''

Revision as of 00:50, 1 July 2008

Image:1frt.png

Template:STRUCTURE 1frt

CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC

Template:ABSTRACT PUBMED 7969498

About this Structure

1FRT is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of rat neonatal Fc receptor with Fc., Burmeister WP, Huber AH, Bjorkman PJ, Nature. 1994 Nov 24;372(6504):379-83. PMID:7969498

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