1ft5

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{{STRUCTURE_1ft5| PDB=1ft5 | SCENE= }}
{{STRUCTURE_1ft5| PDB=1ft5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE OXIDIZED STATE OF CYTOCHROME C554 FROM NITROSOMONAS EUROPAEA'''
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===CRYSTAL STRUCTURE OF THE OXIDIZED STATE OF CYTOCHROME C554 FROM NITROSOMONAS EUROPAEA===
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==Overview==
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Cytochrome c554 (cyt c554) is a tetra-heme cytochrome involved in the oxidation of NH3 by Nitrosomonas europaea. The X-ray crystal structures of both the oxidized and dithionite-reduced states of cyt c554 in a new, rhombohedral crystal form have been solved by molecular replacement, at 1.6 A and 1.8 A resolution, respectively. Upon reduction, the conformation of the polypeptide chain changes between residues 175 and 179, which are adjacent to hemes III and IV. Cyt c554 displays conserved heme-packing motifs that are present in other heme-containing proteins. Comparisons to hydroxylamine oxidoreductase, the electron donor to cyt c554, and cytochrome c nitrite reductase, an enzyme involved in nitrite ammonification, reveal substantial structural similarity in the polypeptide chain surrounding the heme core environment. The structural determinants of these heme-packing motifs extend to the buried water molecules that hydrogen bond to the histidine ligands to the heme iron. In the original structure determination of a tetragonal crystal form, a cis peptide bond between His129 and Phe130 was identified that appeared to be stabilized by crystal contacts. In the rhombohedral crystal form used in the present high-resolution structure determination, this peptide bond adopts the trans conformation, but with disallowed angles of phi and psi.
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(as it appears on PubMed at http://www.pubmed.gov), where 11372197 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11372197}}
==About this Structure==
==About this Structure==
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[[Category: Rees, D C.]]
[[Category: Rees, D C.]]
[[Category: Heme-stacking]]
[[Category: Heme-stacking]]
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Revision as of 00:54, 1 July 2008

Image:1ft5.png

Template:STRUCTURE 1ft5

CRYSTAL STRUCTURE OF THE OXIDIZED STATE OF CYTOCHROME C554 FROM NITROSOMONAS EUROPAEA

Template:ABSTRACT PUBMED 11372197

About this Structure

1FT5 is a Single protein structure of sequence from Nitrosomonas europaea. Full crystallographic information is available from OCA.

Reference

High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea., Iverson TM, Arciero DM, Hooper AB, Rees DC, J Biol Inorg Chem. 2001 Apr;6(4):390-7. PMID:11372197

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