1fu6

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{{STRUCTURE_1fu6| PDB=1fu6 | SCENE= }}
{{STRUCTURE_1fu6| PDB=1fu6 | SCENE= }}
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'''NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE'''
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===NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE===
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==Overview==
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The N-terminal src homology 2 (SH2) domain of the p85 subunit of phosphoinositide 3-kinase (PI3K) has a higher affinity for a peptide with two phosphotyrosines than for the same peptide with only one. This unexpected result was not observed for the C-terminal SH2 from the same protein. NMR structural analysis has been used to understand the behavior of the N-SH2. The structure of the free SH2 domain has been compared to that of the SH2 complexed with a doubly phosphorylated peptide derived from polyomavirus middle T antigen (MT). The structure of the free SH2 domain shows some differences from previous NMR and X-ray structures. In the N-SH2 complexed with a doubly phosphorylated peptide, a second site for phosphotyrosine interaction has been identified. Further, line shapes of NMR signals showed that the SH2 protein-ligand complex is subject to temperature-dependent conformational mobility. Conformational mobility is also supported by the spectra of the ligand peptide. A binding model which accounts for these results is developed.
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{{ABSTRACT_PUBMED_11123912}}
==About this Structure==
==About this Structure==
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1FU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU6 OCA].
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1FU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU6 OCA].
==Reference==
==Reference==
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[[Category: Weber, T.]]
[[Category: Weber, T.]]
[[Category: Central beta-sheet with two flanking alpha-helice]]
[[Category: Central beta-sheet with two flanking alpha-helice]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:46:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:57:15 2008''

Revision as of 00:57, 1 July 2008

Image:1fu6.png

Template:STRUCTURE 1fu6

NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE

Template:ABSTRACT PUBMED 11123912

About this Structure

1FU6 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site., Weber T, Schaffhausen B, Liu Y, Gunther UL, Biochemistry. 2000 Dec 26;39(51):15860-9. PMID:11123912

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