1fuv

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[[Image:1fuv.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1fuv| PDB=1fuv | SCENE= }}
{{STRUCTURE_1fuv| PDB=1fuv | SCENE= }}
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'''SOLUTION STRUCTURE OF AN RGD PEPTIDE ISOMER-A'''
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===SOLUTION STRUCTURE OF AN RGD PEPTIDE ISOMER-A===
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==Overview==
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The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the activities of the matrix proteins. Depending on the context of the RGD sequence, an RGD-containing peptide may bind to all of the RGD-directed integrins, to a few, or to only a single one. We have previously isolated from a phage-displayed peptide library a cyclic peptide that binds avidly to the alpha(v)beta3 and alpha(v)beta5 integrins but does not bind to other closely related integrins. This peptide, ACDCRGDCFCG, exists in two natural configurations depending on internal disulfide bonding. The peptide with the 1-4; 2-3 disulfide bond arrangement accounts for most of the alpha(v) integrin binding activity, whereas the 1-3; 2-4 peptide is about 10-fold less potent. Solution structure analysis by nuclear magnetic resonance reveals an entirely different presentation of the RGD motif in the two isomers of RGD-4C. These results provide new insight into the ligand recognition specificity of integrins.
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The line below this paragraph, {{ABSTRACT_PUBMED_11327857}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11327857 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11327857}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUV OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FUV OCA].
==Reference==
==Reference==
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[[Category: Double s-s bond]]
[[Category: Double s-s bond]]
[[Category: Type i beta-turn]]
[[Category: Type i beta-turn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:47:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:58:51 2008''

Revision as of 00:58, 1 July 2008

Image:1fuv.png

Template:STRUCTURE 1fuv

SOLUTION STRUCTURE OF AN RGD PEPTIDE ISOMER-A

Template:ABSTRACT PUBMED 11327857

About this Structure

Full experimental information is available from OCA.

Reference

Solution structures and integrin binding activities of an RGD peptide with two isomers., Assa-Munt N, Jia X, Laakkonen P, Ruoslahti E, Biochemistry. 2001 Feb 27;40(8):2373-8. PMID:11327857

Page seeded by OCA on Tue Jul 1 03:58:51 2008

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