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{{STRUCTURE_1fv7| PDB=1fv7 | SCENE= }}
{{STRUCTURE_1fv7| PDB=1fv7 | SCENE= }}
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'''A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX'''
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===A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX===
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==Overview==
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Natural and artificial oligonucleotides are capable of assuming many different conformations and functions. Here we present results of an NMR restrained molecular modelling study on the conformational preferences of the modified decanucleotide d((m)C1G2(m)C3G4C5(L)G6(L)(m)C7G8(m)C9G10) .d((m)C11G12(m)C13G14C15(L)G (L)16(m)C17-G18(m)C19G20 ) which contains L deoxynucleotides in its centre. This chimeric DNA was expected to form a right-left-right-handed B-type double-helix (BB*B) at low salt concentration. Actually, it matured into a fully right-handed double helix with its central C(L)pG(L) core forming a right-handed Z-DNA helix embedded in a B-DNA matrix (BZ*B). The interplay between base-base and base-sugar stackings within the core and its immediately adjacent residues was found to be critical in ensuring the stabilisation of the right-handed helix. The structure could serve as a model for the design of antisense oligonucleotides resistant to nucleases and capable of hybridising to natural DNAs and RNAs.
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(as it appears on PubMed at http://www.pubmed.gov), where 11071926 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11071926}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV7 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FV7 OCA].
==Reference==
==Reference==
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[[Category: Dna polymorphism]]
[[Category: Dna polymorphism]]
[[Category: L enantiomery]]
[[Category: L enantiomery]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:48:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:59:37 2008''

Revision as of 00:59, 1 July 2008

Image:1fv7.png

Template:STRUCTURE 1fv7

A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX

Template:ABSTRACT PUBMED 11071926

About this Structure

Full experimental information is available from OCA.

Reference

A two B-Z junction containing DNA resolves into an all right-handed double-helix., Mauffret O, El Amri C, Santamaria F, Tevanian G, Rayner B, Fermandjian S, Nucleic Acids Res. 2000 Nov 15;28(22):4403-9. PMID:11071926

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