1fvh

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{{STRUCTURE_1fvh| PDB=1fvh | SCENE= }}
{{STRUCTURE_1fvh| PDB=1fvh | SCENE= }}
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'''CRYSTAL STRUCTURE ANALYSIS OF NEURONAL SEC1 FROM THE SQUID L. PEALEI'''
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===CRYSTAL STRUCTURE ANALYSIS OF NEURONAL SEC1 FROM THE SQUID L. PEALEI===
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==Overview==
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Sec1 molecules associate with t-SNAREs from the syntaxin family in a heterodimeric complex that plays an essential role in vesicle transport and membrane fusion. Neuronal rat n-Sec1 has an arch-shaped three-domain structure, which binds syntaxin 1a through contacts in domains 1 and 3. In both rat nSec1 and homologous squid s-Sec1, a potential effector-molecule binding-pocket is shaped by residues from domains 1 and 2 and is localized on the opposite side of the syntaxin 1a interaction site. Comparison of several crystal forms of unliganded neuronal squid Sec1 indicates a hinge region between domains 1 and 2 which allows domain 1 to rotate along a central axis. This movement could release syntaxin 1a upon interaction with a yet unspecified Sec1 effector molecule(s). The binding of an effector protein may also directly affect the conformation of the helical hairpin of domain 3, which contributes the other significant syntaxin 1a binding sites in the rat nSec1/syntaxin 1a complex structure but adopts multiple conformations in the unliganded s-Sec1 structures reported here.
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The line below this paragraph, {{ABSTRACT_PUBMED_11178889}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11178889 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11178889}}
==About this Structure==
==About this Structure==
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[[Category: Left-hand turn connection]]
[[Category: Left-hand turn connection]]
[[Category: Parallel beta-sheet]]
[[Category: Parallel beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:48:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:00:18 2008''

Revision as of 01:00, 1 July 2008

Image:1fvh.png

Template:STRUCTURE 1fvh

CRYSTAL STRUCTURE ANALYSIS OF NEURONAL SEC1 FROM THE SQUID L. PEALEI

Template:ABSTRACT PUBMED 11178889

About this Structure

1FVH is a Single protein structure of sequence from Loligo pealei. Full crystallographic information is available from OCA.

Reference

Crystal structures of neuronal squid Sec1 implicate inter-domain hinge movement in the release of t-SNAREs., Bracher A, Weissenhorn W, J Mol Biol. 2001 Feb 9;306(1):7-13. PMID:11178889

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