1fvn

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[[Image:1fvn.gif|left|200px]]
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{{Seed}}
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[[Image:1fvn.png|left|200px]]
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{{STRUCTURE_1fvn| PDB=1fvn | SCENE= }}
{{STRUCTURE_1fvn| PDB=1fvn | SCENE= }}
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'''[ALA31, AIB32]-NEUROPEPTIDE Y'''
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===[ALA31, AIB32]-NEUROPEPTIDE Y===
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==Overview==
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The first Y(5) receptor-selective analog of neuropeptide Y (NPY), [Ala(31),Aib(32)]NPY, has been developed and biologically characterized. Using competition binding assays on cell lines that express different Y receptors, we determined the affinity of this analog to be 6 nm at the human Y(5) receptor, &gt;500 nm at the Y(1) and Y(2) receptors, and &gt;1000 nm at the Y(4) receptor. Activity studies performed in vitro using a cAMP enzyme immunoassay, and in vivo using food intake studies in rats, showed that the peptide acted as an agonist. Further peptides obtained by the combination of the Ala(31)-Aib(32) motif with chimeric peptides containing segments of NPY and pancreatic polypeptide displayed the same selectivity and even higher affinity (up to 0.2 nm) for the Y(5) receptor. In vivo administration of the new Y(5) receptor-selective agonists significantly stimulated feeding in rats. The NMR solution structures of NPY and [Ala(31),Aib(32)]NPY showed a different conformation in the C-terminal region, where the alpha-helix of NPY was substituted by a more flexible, 3(10)-helical turn structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_10944518}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10944518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10944518}}
==About this Structure==
==About this Structure==
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1FVN is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVN OCA].
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1FVN is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVN OCA].
==Reference==
==Reference==
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[[Category: 310-helix]]
[[Category: 310-helix]]
[[Category: Alpha]]
[[Category: Alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:48:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:00:41 2008''

Revision as of 01:00, 1 July 2008

Image:1fvn.png

Template:STRUCTURE 1fvn

[ALA31, AIB32]-NEUROPEPTIDE Y

Template:ABSTRACT PUBMED 10944518

About this Structure

1FVN is a Single protein structure. Full experimental information is available from OCA.

Reference

The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats., Cabrele C, Langer M, Bader R, Wieland HA, Doods HN, Zerbe O, Beck-Sickinger AG, J Biol Chem. 2000 Nov 17;275(46):36043-8. PMID:10944518

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