1fvv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1fvv.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1fvv.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1fvv| PDB=1fvv | SCENE= }}
{{STRUCTURE_1fvv| PDB=1fvv | SCENE= }}
-
'''THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR'''
+
===THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR===
-
==Overview==
+
<!--
-
Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11141566}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11141566 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11141566}}
==About this Structure==
==About this Structure==
Line 51: Line 55:
[[Category: Cyclin some]]
[[Category: Cyclin some]]
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:49:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:01:12 2008''

Revision as of 01:01, 1 July 2008

Image:1fvv.png

Template:STRUCTURE 1fvv

THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR

Template:ABSTRACT PUBMED 11141566

About this Structure

1FVV is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors., Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, Eberwein DJ, Edelstein M, Frye SV, Gampe Jr RT, Griffin RJ, Harris PA, Hassell AM, Holmes WD, Hunter RN, Knick VB, Lackey K, Lovejoy B, Luzzio MJ, Murray D, Parker P, Rocque WJ, Shewchuk L, Veal JM, Walker DH, Kuyper LF, Science. 2001 Jan 5;291(5501):134-7. PMID:11141566

Page seeded by OCA on Tue Jul 1 04:01:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fvv"
Personal tools