1fvu

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[[Image:1fvu.gif|left|200px]]
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{{Seed}}
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[[Image:1fvu.png|left|200px]]
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{{STRUCTURE_1fvu| PDB=1fvu | SCENE= }}
{{STRUCTURE_1fvu| PDB=1fvu | SCENE= }}
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'''CRYSTAL STRUCTURE OF BOTROCETIN'''
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===CRYSTAL STRUCTURE OF BOTROCETIN===
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==Overview==
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The binding of von Willebrand factor (vWF) to the platelet receptor, glycoprotein (GP) Ib-IX-V complex, has a key role in the initiation of thrombus formation and is regulated by interactions with extracellular matrix components under the influence of hemodynamic forces. To a certain extent, these effects can be mimicked in vitro by two nonphysiologic modulators, ristocetin and botrocetin. The latter, isolated from the venom of the snake Bothrops jararaca, is a 31-kDa heterodimeric protein that forms a soluble complex with vWF. As an initial step toward understanding the mechanisms that regulate vWF function, we have solved the crystal structure of botrocetin at 1.8 A resolution. Botrocetin exhibits homology with other snake proteins, but contains only one metal binding site as compared to two in Factor IX binding protein and Factor IX/X binding protein and none in flavocetin. A distinctive feature of botrocetin is the presence of a negatively charged surface that may play a role in the association with the vWF A1 domain.
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The line below this paragraph, {{ABSTRACT_PUBMED_11148028}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11148028 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11148028}}
==About this Structure==
==About this Structure==
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[[Category: Metal-binding]]
[[Category: Metal-binding]]
[[Category: Von willbrand factor modulator]]
[[Category: Von willbrand factor modulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:49:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:01:13 2008''

Revision as of 01:01, 1 July 2008

Image:1fvu.png

Template:STRUCTURE 1fvu

CRYSTAL STRUCTURE OF BOTROCETIN

Template:ABSTRACT PUBMED 11148028

About this Structure

1FVU is a Protein complex structure of sequences from Bothrops jararaca. Full crystallographic information is available from OCA.

Reference

Crystal structure of the von Willebrand factor modulator botrocetin., Sen U, Vasudevan S, Subbarao G, McClintock RA, Celikel R, Ruggeri ZM, Varughese KI, Biochemistry. 2001 Jan 16;40(2):345-52. PMID:11148028

Page seeded by OCA on Tue Jul 1 04:01:13 2008

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