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1fwq

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[[Image:1fwq.gif|left|200px]]
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{{STRUCTURE_1fwq| PDB=1fwq | SCENE= }}
{{STRUCTURE_1fwq| PDB=1fwq | SCENE= }}
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'''SOLUTION STRUCTURE OF HUMAN MSS4, A GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB PROTEINS'''
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===SOLUTION STRUCTURE OF HUMAN MSS4, A GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB PROTEINS===
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==Overview==
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Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4), has been identified. Here we use multidimensional NMR to determine the structure of human Mss4 (hMss4), which is the first tertiary structure established for a protein with GEF activity. Mss4 contains a central beta-sheet sandwiched between two small sheets. It also binds a Zn2+ ion through Cys 23, Cys 26, Cys 94 and Cys 97. The Rab-binding surface of hMss4 has subsequently been delineated using chemical-shift perturbation experiments and site-directed mutagenesis. The active site of hMss4 involves the Zn(2+)-binding region and a neighbouring loop.
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The line below this paragraph, {{ABSTRACT_PUBMED_7651540}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7651540 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7651540}}
==About this Structure==
==About this Structure==
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1FWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FWQ OCA].
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1FWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FWQ OCA].
==Reference==
==Reference==
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[[Category: Beta structure]]
[[Category: Beta structure]]
[[Category: Zinc-binding]]
[[Category: Zinc-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:51:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:03:32 2008''

Revision as of 01:03, 1 July 2008

Image:1fwq.png

Template:STRUCTURE 1fwq

SOLUTION STRUCTURE OF HUMAN MSS4, A GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB PROTEINS

Template:ABSTRACT PUBMED 7651540

About this Structure

1FWQ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface., Yu H, Schreiber SL, Nature. 1995 Aug 31;376(6543):788-91. PMID:7651540

Page seeded by OCA on Tue Jul 1 04:03:32 2008

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