1fyo

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[[Image:1fyo.gif|left|200px]]
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{{Seed}}
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[[Image:1fyo.png|left|200px]]
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{{STRUCTURE_1fyo| PDB=1fyo | SCENE= }}
{{STRUCTURE_1fyo| PDB=1fyo | SCENE= }}
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'''EUKARYOTIC DECODING REGION A-SITE RNA'''
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===EUKARYOTIC DECODING REGION A-SITE RNA===
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==Overview==
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The aminoglycoside antibiotics target a region of highly conserved nucleotides in the aminoacyl-tRNA site (A site) of 16 S RNA on the 30 S subunit. The structures of a prokaryotic decoding region A-site oligonucleotide free in solution and bound to the aminoglycosides paromomycin and gentamicin C1A have been determined. Here, the structure of a eukaryotic decoding region A-site oligonucleotide has been determined using homonuclear and heteronuclear NMR spectroscopy, and compared to the unbound prokaryotic rRNA structure. The two structures are similar, with a U1406-U1495 base-pair, a C1407-G1494 Watson-Crick base-pair, and a G1408-A1493 base-pair instead of the A1408-A1493 base-pair of the prokaryotic structure. The two structures differ in the orientation of the 1408 position with respect to A1493; G1408 is rotated toward the major groove, which is the binding pocket for aminoglycosides. The structures also differ in the stacking geometry of G1494 on A1493, which could have slight long-range conformational effects.
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The line below this paragraph, {{ABSTRACT_PUBMED_11237616}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11237616 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11237616}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYO OCA].
==Reference==
==Reference==
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[[Category: G-a base pair]]
[[Category: G-a base pair]]
[[Category: Stem-internal loop-stem-tetraloop rna]]
[[Category: Stem-internal loop-stem-tetraloop rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:54:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:08:25 2008''

Revision as of 01:08, 1 July 2008

Image:1fyo.png

Template:STRUCTURE 1fyo

EUKARYOTIC DECODING REGION A-SITE RNA

Template:ABSTRACT PUBMED 11237616

About this Structure

Full experimental information is available from OCA.

Reference

Structure of a eukaryotic decoding region A-site RNA., Lynch SR, Puglisi JD, J Mol Biol. 2001 Mar 9;306(5):1023-35. PMID:11237616

Page seeded by OCA on Tue Jul 1 04:08:25 2008

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