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1fyx

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{{STRUCTURE_1fyx| PDB=1fyx | SCENE= }}
{{STRUCTURE_1fyx| PDB=1fyx | SCENE= }}
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'''CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2'''
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===CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2===
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==Overview==
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Toll-like receptors (TLRs) and the interleukin-1 receptor superfamily (IL-1Rs) are integral to both innate and adaptive immunity for host defence. These receptors share a conserved cytoplasmic domain, known as the TIR domain. A single-point mutation in the TIR domain of murine TLR4 (Pro712His, the Lps(d) mutation) abolishes the host immune response to lipopolysaccharide (LPS), and mutation of the equivalent residue in TLR2, Pro681His, disrupts signal transduction in response to stimulation by yeast and gram-positive bacteria. Here we report the crystal structures of the TIR domains of human TLR1 and TLR2 and of the Pro681His mutant of TLR2. The structures have a large conserved surface patch that also contains the site of the Lps(d) mutation. Mutagenesis and functional studies confirm that residues in this surface patch are crucial for receptor signalling. The Lps(d) mutation does not disturb the structure of the TIR domain itself. Instead, structural and functional studies indicate that the conserved surface patch may mediate interactions with the down-stream MyD88 adapter molecule, and that the Lps(d) mutation may abolish receptor signalling by disrupting this recruitment.
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(as it appears on PubMed at http://www.pubmed.gov), where 11081518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11081518}}
==About this Structure==
==About this Structure==
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[[Category: Xu, Y.]]
[[Category: Xu, Y.]]
[[Category: Beta-alpha-beta fold]]
[[Category: Beta-alpha-beta fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:55:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:08:54 2008''

Revision as of 01:08, 1 July 2008

Image:1fyx.png

Template:STRUCTURE 1fyx

CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2

Template:ABSTRACT PUBMED 11081518

About this Structure

1FYX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains., Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L, Nature. 2000 Nov 2;408(6808):111-5. PMID:11081518

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