1g13

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1g13.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1g13.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g13| PDB=1g13 | SCENE= }}
{{STRUCTURE_1g13| PDB=1g13 | SCENE= }}
-
'''HUMAN GM2 ACTIVATOR STRUCTURE'''
+
===HUMAN GM2 ACTIVATOR STRUCTURE===
-
==Overview==
+
<!--
-
GM2 activator protein (GM2-AP) belongs to a small group of non- enzymatic lysosomal proteins that act as cofactors in the sequential degradation of gangliosides. It has been postulated that GM2-AP extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-d-galactosamine and conversion to GM3. The high affinity of GM2-AP for GM2 is based on specfic recognition of the oligosaccharide moiety as well as the ceramide lipid tail. Genetic defects in GM2-AP result in an atypical form of Tay-Sachs disease known as variant AB GM2 gangliosidosis. The 2.0 A resolution crystal structure of GM2-AP reported here reveals a previously unobserved fold whose main feature is an eight-stranded cup-shaped anti-parallel beta-pleated sheet. The striking feature of the GM2-AP structure is that it possesses an accessible central hydrophobic cavity rather than a buried hydrophobic core. The dimensions of this cavity (12 Ax14 Ax22 A) are suitable for binding 18-carbon lipid acyl chains. Flexible surface loops and a short alpha-helix decorate the mouth of the beta-cup and may control lipid entry to the cavity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11090283}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11090283 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11090283}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Wright, C S.]]
[[Category: Wright, C S.]]
[[Category: Beta cup]]
[[Category: Beta cup]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:59:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:14:44 2008''

Revision as of 01:14, 1 July 2008

Image:1g13.png

Template:STRUCTURE 1g13

HUMAN GM2 ACTIVATOR STRUCTURE

Template:ABSTRACT PUBMED 11090283

About this Structure

1G13 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human GM2-activator protein with a novel beta-cup topology., Wright CS, Li SC, Rastinejad F, J Mol Biol. 2000 Dec 1;304(3):411-22. PMID:11090283

Page seeded by OCA on Tue Jul 1 04:14:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g13"
Personal tools