1g1o

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[[Image:1g1o.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1g1o| PDB=1g1o | SCENE= }}
{{STRUCTURE_1g1o| PDB=1g1o | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S'''
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===CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S===
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==Overview==
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Transthyretin is a tetrameric plasma protein associated with two forms of amyloid disease. The structure of the highly amyloidogenic transthyretin triple mutant TTRG53S/E54D/L55S determined at 2.3 A resolution reveals a novel conformation: the beta-slip. A three-residue shift in beta strand D places Leu-58 at the position normally occupied by Leu-55 now mutated to serine. The beta-slip is best defined in two of the four monomers, where it makes new protein-protein interactions to an area normally involved in complex formation with retinol-binding protein. This interaction creates unique packing arrangements, where two protein helices combine to form a double helix in agreement with fiber diffraction and electron microscopy data. Based on these findings, a novel model for transthyretin amyloid formation is presented.
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(as it appears on PubMed at http://www.pubmed.gov), where 11106758 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11106758}}
==About this Structure==
==About this Structure==
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[[Category: Beta-slip]]
[[Category: Beta-slip]]
[[Category: Greek key]]
[[Category: Greek key]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:01:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:16:26 2008''

Revision as of 01:16, 1 July 2008

Image:1g1o.png

Template:STRUCTURE 1g1o

CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S

Template:ABSTRACT PUBMED 11106758

About this Structure

1G1O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The beta-slip: a novel concept in transthyretin amyloidosis., Eneqvist T, Andersson K, Olofsson A, Lundgren E, Sauer-Eriksson AE, Mol Cell. 2000 Nov;6(5):1207-18. PMID:11106758

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