1g25

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[[Image:1g25.gif|left|200px]]
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{{Seed}}
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[[Image:1g25.png|left|200px]]
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{{STRUCTURE_1g25| PDB=1g25 | SCENE= }}
{{STRUCTURE_1g25| PDB=1g25 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN TFIIH MAT1 SUBUNIT'''
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===SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN TFIIH MAT1 SUBUNIT===
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==Overview==
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The human MAT1 protein belongs to the cyclin-dependent kinase-activating kinase complex, which is functionally associated to the transcription/DNA repair factor TFIIH. The N-terminal region of MAT1 consists of a C3HC4 RING finger, which contributes to optimal TFIIH transcriptional activities. We report here the solution structure of the human MAT1 RING finger domain (Met(1)-Asp(65)) as determined by (1)H NMR spectroscopy. The MAT1 RING finger domain presents the expected betaalphabetabeta topology with two interleaved zinc-binding sites conserved among the RING family. However, the presence of an additional helical segment in the N-terminal part of the domain and a conserved hydrophobic central beta strand are the defining features of this new structure and more generally of the MAT1 RING finger subfamily. Comparison of electrostatic surfaces of RING finger structures shows that the RING finger domain of MAT1 presents a remarkable positively charged surface. The functional implications of these MAT1 RING finger features are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 11056162 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11056162}}
==About this Structure==
==About this Structure==
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1G25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G25 OCA].
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1G25 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G25 OCA].
==Reference==
==Reference==
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[[Category: Thierry, J C.]]
[[Category: Thierry, J C.]]
[[Category: Wasielewski, E.]]
[[Category: Wasielewski, E.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:02:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:17:41 2008''

Revision as of 01:17, 1 July 2008

Image:1g25.png

Template:STRUCTURE 1g25

SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN TFIIH MAT1 SUBUNIT

Template:ABSTRACT PUBMED 11056162

About this Structure

1G25 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family., Gervais V, Busso D, Wasielewski E, Poterszman A, Egly JM, Thierry JC, Kieffer B, J Biol Chem. 2001 Mar 9;276(10):7457-64. Epub 2000 Oct 30. PMID:11056162

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