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1g2e

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{{STRUCTURE_1g2e| PDB=1g2e | SCENE= }}
{{STRUCTURE_1g2e| PDB=1g2e | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA'''
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===CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA===
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==Overview==
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Hu proteins bind to adenosine-uridine (AU)-rich elements (AREs) in the 3' untranslated regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal structures of the first two RNA recognition motif (RRM) domains of the HuD protein in complex with an 11-nucleotide fragment of a class I ARE (the c-fos ARE; to 1.8 A), and with an 11-nucleotide fragment of a class II ARE (the tumor necrosis factor alpha ARE; to 2.3 A). These structures reveal a consensus RNA recognition sequence that suggests a preference for pyrimidine-rich sequences and a requirement for a central uracil residue in the clustered AUUUA repeats found in class II AREs. Comparison to structures of other RRM domain-nucleic acid complexes reveals two base recognition pockets in all the structures that interact with bases using residues in conserved ribonucleoprotein motifs and at the C-terminal ends of RRM domains. Different conformations of nucleic acid can be bound by RRM domains by using different combinations of base recognition pockets and multiple RRM domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 11175903 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11175903}}
==About this Structure==
==About this Structure==
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[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
[[Category: Tumor necrosis factor]]
[[Category: Tumor necrosis factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:03:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:18:27 2008''

Revision as of 01:18, 1 July 2008

Image:1g2e.png

Template:STRUCTURE 1g2e

CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA

Template:ABSTRACT PUBMED 11175903

About this Structure

1G2E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of AU-rich element RNA by the HuD protein., Wang X, Tanaka Hall TM, Nat Struct Biol. 2001 Feb;8(2):141-5. PMID:11175903

Page seeded by OCA on Tue Jul 1 04:18:27 2008

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