1g37

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1g37.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1g37.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1g37| PDB=1g37 | SCENE= }}
{{STRUCTURE_1g37| PDB=1g37 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE'''
+
===CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE===
-
==Overview==
+
<!--
-
Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11212093}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11212093 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11212093}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Protease]]
[[Category: Protease]]
[[Category: Thrombin]]
[[Category: Thrombin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:04:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:20:43 2008''

Revision as of 01:20, 1 July 2008

Template:STRUCTURE 1g37

CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH BCH-10556 AND EXOSITE-DIRECTED PEPTIDE

Template:ABSTRACT PUBMED 11212093

About this Structure

1G37 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors., Bachand B, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA, Bioorg Med Chem Lett. 2001 Feb 12;11(3):287-90. PMID:11212093

Page seeded by OCA on Tue Jul 1 04:20:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools