1g44

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{{STRUCTURE_1g44| PDB=1g44 | SCENE= }}
{{STRUCTURE_1g44| PDB=1g44 | SCENE= }}
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'''CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS'''
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===CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS===
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==Overview==
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Vaccinia virus complement control protein (VCP) inhibits both pathways of complement activation through binding the third and fourth components. A homolog of mammalian regulators of complement activation, its ability to bind heparin endows VCP with additional activities of significance to viral infectivity. The structure of VCP reveals a highly extended molecule with a putative heparin recognition site at its C-terminal end. A second cluster of positive charges provides a possibly overlapping binding site for both heparin and complement components. Experiments suggested by the structure indicate that VCP can bind heparin and control complement simultaneously. This, the structure of any intact regulator of complement activation, along with attendant functional insights, will stimulate the design of new therapeutic inhibitors of complement.
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The line below this paragraph, {{ABSTRACT_PUBMED_11207370}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11207370 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11207370}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:06:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:23:03 2008''

Revision as of 01:23, 1 July 2008

Image:1g44.png

Template:STRUCTURE 1g44

CRYSTAL STRUCTURE OF A COMPLEMENT CONTROL PROTEIN THAT REGULATES BOTH PATHWAYS OF COMPLEMENT ACTIVATION AND BINDS HEPARAN SULFATE PROTEOGLYCANS

Template:ABSTRACT PUBMED 11207370

About this Structure

1G44 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans., Murthy KH, Smith SA, Ganesh VK, Judge KW, Mullin N, Barlow PN, Ogata CM, Kotwal GJ, Cell. 2001 Jan 26;104(2):301-11. PMID:11207370

Page seeded by OCA on Tue Jul 1 04:23:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA, Eric Martz

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