1g4k

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{{STRUCTURE_1g4k| PDB=1g4k | SCENE= }}
{{STRUCTURE_1g4k| PDB=1g4k | SCENE= }}
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'''X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin'''
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===X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin===
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==Overview==
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A new class of matrix metalloproteinase (MMP) inhibitors has been identified by screening a collection of compounds against stromelysin. The inhibitors, 2,4,6-pyrimidine triones, have proven to be potent inhibitors of gelatinases A and B. An X-ray crystal structure of one representative compound bound to the catalytic domain of stromelysin shows that the compounds bind at the active site and ligand the active-site zinc. The pyrimidine triones mimic substrates in forming hydrogen bonds to key residues in the active site, and provide opportunities for placing appropriately chosen groups into the S1' specificity pocket of MMPS: A number of compounds have been synthesized and assayed against stromelysin, and the variations in potency are explained in terms of the binding mode revealed in the X-ray crystal structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 11316871 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11316871}}
==About this Structure==
==About this Structure==
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[[Category: Stomelysin]]
[[Category: Stomelysin]]
[[Category: Zinc ligand]]
[[Category: Zinc ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:07:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:24:22 2008''

Revision as of 01:24, 1 July 2008

Image:1g4k.png

Template:STRUCTURE 1g4k

X-ray Structure of a Novel Matrix Metalloproteinase Inhibitor Complexed to Stromelysin

Template:ABSTRACT PUBMED 11316871

About this Structure

1G4K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin., Dunten P, Kammlott U, Crowther R, Levin W, Foley LH, Wang P, Palermo R, Protein Sci. 2001 May;10(5):923-6. PMID:11316871

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