1g4w

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{{STRUCTURE_1g4w| PDB=1g4w | SCENE= }}
{{STRUCTURE_1g4w| PDB=1g4w | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP'''
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===CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP===
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==Overview==
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Salmonella spp. utilize a specialized protein secretion system to deliver a battery of effector proteins into host cells. Several of these effectors stimulate Cdc42- and Rac1-dependent cytoskeletal changes that promote bacterial internalization. These potentially cytotoxic alterations are rapidly reversed by the effector SptP, a tyrosine phosphatase and GTPase activating protein (GAP) that targets Cdc42 and Rac1. The 2.3 A resolution crystal structure of an SptP-Rac1 transition state complex reveals an unusual GAP architecture that mimics host functional homologs. The phosphatase domain possesses a conserved active site but distinct surface properties. Binding to Rac1 induces a dramatic stabilization in SptP of a four-helix bundle that makes extensive contacts with the Switch I and Switch II regions of the GTPase.
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(as it appears on PubMed at http://www.pubmed.gov), where 11163217 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11163217}}
==About this Structure==
==About this Structure==
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[[Category: Tyrosine phosphatase]]
[[Category: Tyrosine phosphatase]]
[[Category: Virulence factor]]
[[Category: Virulence factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:08:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:25:01 2008''

Revision as of 01:25, 1 July 2008

Image:1g4w.png

Template:STRUCTURE 1g4w

CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP

Template:ABSTRACT PUBMED 11163217

About this Structure

1G4W is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1., Stebbins CE, Galan JE, Mol Cell. 2000 Dec;6(6):1449-60. PMID:11163217

Page seeded by OCA on Tue Jul 1 04:25:01 2008

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