6tmn

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(New page: 200px<br /><applet load="6tmn" size="450" color="white" frame="true" align="right" spinBox="true" caption="6tmn, resolution 1.6&Aring;" /> '''STRUCTURES OF TWO THE...)
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Revision as of 13:11, 20 November 2007

Image:6tmn.gif

6tmn, resolution 1.6Å

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STRUCTURES OF TWO THERMOLYSIN-INHIBITOR COMPLEXES THAT DIFFER BY A SINGLE HYDROGEN BOND

Overview

The mode of binding to thermolysin of the ester analog, Cbz-GlyP-(O)-Leu-Leu has been determined by x-ray crystallography and, shown to be virtually identical (maximum difference 0.2 angstrom) with the, corresponding peptide analog Cbz-GlyP-(NH)-Leu-Leu. The two inhibitors, provide a matched pair of enzyme-inhibitor complexes that differ by 4.1, kilocalories per mole in intrinsic binding energy but are essentially, identical except for the presence or absence of a specific hydrogen bond.

About this Structure

6TMN is a Single protein structure of sequence from [1] with CA and ZN as ligands. Active as Thermolysin, with EC number 3.4.24.27 Full crystallographic information is available from OCA.

Reference

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond., Tronrud DE, Holden HM, Matthews BW, Science. 1987 Jan 30;235(4788):571-4. PMID:3810156

Page seeded by OCA on Tue Nov 20 15:18:43 2007

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