1g5w

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[[Image:1g5w.jpg|left|200px]]
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{{Seed}}
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[[Image:1g5w.png|left|200px]]
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{{STRUCTURE_1g5w| PDB=1g5w | SCENE= }}
{{STRUCTURE_1g5w| PDB=1g5w | SCENE= }}
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'''SOLUTION STRUCTURE OF HUMAN HEART-TYPE FATTY ACID BINDING PROTEIN'''
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===SOLUTION STRUCTURE OF HUMAN HEART-TYPE FATTY ACID BINDING PROTEIN===
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==Overview==
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Recent advances in the characterization of fatty acid-binding proteins (FABPs) by NMR have enabled various research groups to investigate the function of these proteins in aqueous solution. The binding of fatty acid molecules to FABPs, which proceeds through a portal region on the protein surface, is of particular interest. In the present study we have determined the three-dimensional solution structure of human heart-type FABP by multi-dimensional heteronuclear NMR spectroscopy. Subsequently, in combination with data collected on a F57S mutant we have been able to show that different fatty acids induce distinct conformational states of the protein backbone in this portal region, depending on the chain length of the fatty acid ligand. This indicates that during the binding process the protein accommodates the ligand molecule by a "selected-fit" mechanism. In fact, this behaviour appears to be especially pronounced in the heart-type FABP, possibly due to a more rigid backbone structure compared with other FABPs, as suggested by recent NMR relaxation studies. Thus differences in the dynamic behaviours of these proteins may be the key to understanding the variations in ligand affinity and specificity within the FABP family.
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The line below this paragraph, {{ABSTRACT_PUBMED_11171102}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11171102 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11171102}}
==About this Structure==
==About this Structure==
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1G5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5W OCA].
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1G5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G5W OCA].
==Reference==
==Reference==
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[[Category: Protein-ligand interaction]]
[[Category: Protein-ligand interaction]]
[[Category: Selected-fit binding]]
[[Category: Selected-fit binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:10:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:29:34 2008''

Revision as of 01:29, 1 July 2008

Image:1g5w.png

Template:STRUCTURE 1g5w

SOLUTION STRUCTURE OF HUMAN HEART-TYPE FATTY ACID BINDING PROTEIN

Template:ABSTRACT PUBMED 11171102

About this Structure

1G5W is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Spin-system heterogeneities indicate a selected-fit mechanism in fatty acid binding to heart-type fatty acid-binding protein (H-FABP)., Lucke C, Rademacher M, Zimmerman AW, van Moerkerk HT, Veerkamp JH, Ruterjans H, Biochem J. 2001 Mar 1;354(Pt 2):259-66. PMID:11171102

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