1g60

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{{STRUCTURE_1g60| PDB=1g60 | SCENE= }}
{{STRUCTURE_1g60| PDB=1g60 | SCENE= }}
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'''Crystal Structure of Methyltransferase MboIIa (Moraxella bovis)'''
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===Crystal Structure of Methyltransferase MboIIa (Moraxella bovis)===
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==Overview==
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DNA methyltransferases (MTases) are sequence-specific enzymes which transfer a methyl group from S-adenosyl-L-methionine (AdoMet) to the amino group of either cytosine or adenine within a recognized DNA sequence. Methylation of a base in a specific DNA sequence protects DNA from nucleolytic cleavage by restriction enzymes recognizing the same DNA sequence. We have determined at 1.74 A resolution the crystal structure of a beta-class DNA MTase MboIIA (M.MboIIA) from the bacterium Moraxella bovis, the smallest DNA MTase determined to date. M.MboIIA methylates the 3' adenine of the pentanucleotide sequence 5'-GAAGA-3'. The protein crystallizes with two molecules in the asymmetric unit which we propose to resemble the dimer when M.MboIIA is not bound to DNA. The overall structure of the enzyme closely resembles that of M.RsrI. However, the cofactor-binding pocket in M.MboIIA forms a closed structure which is in contrast to the open-form structures of other known MTases.
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The line below this paragraph, {{ABSTRACT_PUBMED_12954781}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12954781 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12954781}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jun 24 23:47:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:30:44 2008''

Revision as of 01:30, 1 July 2008

Image:1g60.png

Template:STRUCTURE 1g60

Crystal Structure of Methyltransferase MboIIa (Moraxella bovis)

Template:ABSTRACT PUBMED 12954781

About this Structure

1G60 is a Single protein structure of sequence from Moraxella bovis. Full crystallographic information is available from OCA.

Reference

Crystal structure of MboIIA methyltransferase., Osipiuk J, Walsh MA, Joachimiak A, Nucleic Acids Res. 2003 Sep 15;31(18):5440-8. PMID:12954781

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