1g62

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{{STRUCTURE_1g62| PDB=1g62 | SCENE= }}
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'''CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6'''
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===CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6===
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==Overview==
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Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
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(as it appears on PubMed at http://www.pubmed.gov), where 11101899 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101899}}
==About this Structure==
==About this Structure==
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Revision as of 01:32, 1 July 2008

Image:1g62.png

Template:STRUCTURE 1g62

CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6

Template:ABSTRACT PUBMED 11101899

About this Structure

1G62 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899

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