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1g6o

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[[Image:1g6o.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1g6o| PDB=1g6o | SCENE= }}
{{STRUCTURE_1g6o| PDB=1g6o | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP'''
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===CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP===
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==Overview==
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The type IV secretion system of Helicobacter pylori consists of 10--15 proteins responsible for transport of the transforming protein CagA into target epithelial cells. Secretion of CagA crucially depends on the hexameric ATPase, HP0525, a member of the VirB11-PulE family. We present the crystal structure of a binary complex of HP0525 bound to ADP. Each monomer consists of two domains formed by the N- and C-terminal halves of the sequence. ADP is bound at the interface between the two domains. In the hexamer, the N- and C-terminal domains form two rings, which together form a chamber open on one side and closed on the other. A model is proposed in which HP0525 functions as an inner membrane pore, the closure and opening of which is regulated by ATP binding and ADP release.
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The line below this paragraph, {{ABSTRACT_PUBMED_11163218}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11163218 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11163218}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Type iv secretion system]]
[[Category: Type iv secretion system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:45:21 2008''

Revision as of 01:45, 1 July 2008

Image:1g6o.png

Template:STRUCTURE 1g6o

CRYSTAL STRUCTURE OF THE HELICOBACTER PYLORI ATPASE, HP0525, IN COMPLEX WITH ADP

Template:ABSTRACT PUBMED 11163218

About this Structure

1G6O is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system., Yeo HJ, Savvides SN, Herr AB, Lanka E, Waksman G, Mol Cell. 2000 Dec;6(6):1461-72. PMID:11163218

Page seeded by OCA on Tue Jul 1 04:45:21 2008

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