1g6z

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[[Image:1g6z.gif|left|200px]]
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{{Seed}}
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[[Image:1g6z.png|left|200px]]
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{{STRUCTURE_1g6z| PDB=1g6z | SCENE= }}
{{STRUCTURE_1g6z| PDB=1g6z | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN'''
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===SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN===
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==Overview==
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The encapsulation of otherwise transcribable loci within transcriptionally inactive heterochromatin is rapidly gaining recognition as an important mechanism of epigenetic gene regulation. In the fission yeast Schizosaccharomyces pombe, heterochromatinization of the mat2/mat3 loci silences the mating-type information encoded within these loci. Here, we present the solution structure of the chromo domain from the cryptic loci regulator protein Clr4. Clr4 is known to regulate silencing and switching at the mating-type loci and to affect chromatin structure at centromeres. Clr4 and its human and Drosophila homologs have been identified as histone H3-specific methyltransferases, further implicating this family of proteins in chromatin remodeling. Our structure highlights a conserved surface that may be involved in chromo domain-ligand interactions. We have also analyzed two chromo domain mutants (W31G and W41G) that previously were shown to affect silencing and switching in full-length Clr4. Both mutants are significantly destabilized relative to wild-type.
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(as it appears on PubMed at http://www.pubmed.gov), where 11273706 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11273706}}
==About this Structure==
==About this Structure==
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1G6Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Z OCA].
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1G6Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G6Z OCA].
==Reference==
==Reference==
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[[Category: Klar, A J.]]
[[Category: Klar, A J.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:13:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:48:13 2008''

Revision as of 01:48, 1 July 2008

Image:1g6z.png

Template:STRUCTURE 1g6z

SOLUTION STRUCTURE OF THE CLR4 CHROMO DOMAIN

Template:ABSTRACT PUBMED 11273706

About this Structure

1G6Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full experimental information is available from OCA.

Reference

Solution structure, domain features, and structural implications of mutants of the chromo domain from the fission yeast histone methyltransferase Clr4., Horita DA, Ivanova AV, Altieri AS, Klar AJ, Byrd RA, J Mol Biol. 2001 Mar 30;307(3):861-70. PMID:11273706

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