1g70

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{{STRUCTURE_1g70| PDB=1g70 | SCENE= }}
{{STRUCTURE_1g70| PDB=1g70 | SCENE= }}
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'''COMPLEX OF HIV-1 RRE-IIB RNA WITH RSG-1.2 PEPTIDE'''
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===COMPLEX OF HIV-1 RRE-IIB RNA WITH RSG-1.2 PEPTIDE===
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==Overview==
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We have used NMR spectroscopy to determine the solution structure of a complex between an oligonucleotide derived from stem IIB of the Rev responsive element (RRE-IIB) of HIV-1 mRNA and an in vivo selected, high affinity binding Arg-rich peptide. The peptide binds in a partially alpha-helical conformation into a pocket within the RNA deep groove. Comparison with the structure of a complex between an alpha-helical Rev peptide and RRE-IIB reveals that the sequence of the bound peptide determines the local conformation of the RRE peptide binding site. A conformational switch of an unpaired uridine base was revealed; this points out into the solvent in the Rev peptide complex, but it is stabilized inside the RNA deep groove by stacking with an Arg side chain in the selected peptide complex. The conformational switch has been visualized by NMR chemical shift mapping of the uridine H5/H6 atoms during a competition experiment in which Rev peptide was displaced from RRE-IIB by the higher affinity binding selected peptide.
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The line below this paragraph, {{ABSTRACT_PUBMED_11175904}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11175904 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11175904}}
==About this Structure==
==About this Structure==
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1G70 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G70 OCA].
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1G70 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G70 OCA].
==Reference==
==Reference==
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[[Category: Non-canonical base pair]]
[[Category: Non-canonical base pair]]
[[Category: Peptide-rna complex]]
[[Category: Peptide-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:13:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:48:17 2008''

Revision as of 01:48, 1 July 2008

Image:1g70.png

Template:STRUCTURE 1g70

COMPLEX OF HIV-1 RRE-IIB RNA WITH RSG-1.2 PEPTIDE

Template:ABSTRACT PUBMED 11175904

About this Structure

1G70 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA.

Reference

Peptide-triggered conformational switch in HIV-1 RRE RNA complexes., Gosser Y, Hermann T, Majumdar A, Hu W, Frederick R, Jiang F, Xu W, Patel DJ, Nat Struct Biol. 2001 Feb;8(2):146-50. PMID:11175904

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