1g7p

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[[Image:1g7p.gif|left|200px]]
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{{Seed}}
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[[Image:1g7p.png|left|200px]]
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{{STRUCTURE_1g7p| PDB=1g7p | SCENE= }}
{{STRUCTURE_1g7p| PDB=1g7p | SCENE= }}
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'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE'''
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===CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE===
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==Overview==
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The crystal structure of a non-standard peptide, YEA9, in complex with H-2Kb, at 1.5 A resolution demonstrates how YEA9 peptide can bind with surprisingly high affinity through insertion of alternative, long, non-canonical anchors into the B and E pockets. The use of "alternative pockets" represents a new mode of high affinity peptide binding, that should be considered when predicting peptide epitopes for MHC class I. These novel interactions encountered in this non-canonical high affinity peptide-MHC complex should help predict additional binding peptides from primary protein sequences and aid in the design of alternative approaches for peptide-based vaccines.
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The line below this paragraph, {{ABSTRACT_PUBMED_12083519}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12083519 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12083519}}
==About this Structure==
==About this Structure==
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[[Category: S. cerevisiae]]
[[Category: S. cerevisiae]]
[[Category: Yeast]]
[[Category: Yeast]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:14:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:50:33 2008''

Revision as of 01:50, 1 July 2008

Image:1g7p.png

Template:STRUCTURE 1g7p

CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE

Template:ABSTRACT PUBMED 12083519

About this Structure

1G7P is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors., Apostolopoulos V, Yu M, Corper AL, Li W, McKenzie IF, Teyton L, Wilson IA, Plebanski M, J Mol Biol. 2002 May 17;318(5):1307-16. PMID:12083519

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