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1g7q

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{{STRUCTURE_1g7q| PDB=1g7q | SCENE= }}
{{STRUCTURE_1g7q| PDB=1g7q | SCENE= }}
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'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA'''
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===CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA===
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==Overview==
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Peptides bind with high affinity to MHC class I molecules by anchoring certain side-chains (anchors) into specificity pockets in the MHC peptide-binding groove. Peptides that do not contain these canonical anchor residues normally have low affinity, resulting in impaired pMHC stability and loss of immunogenicity. Here, we report the crystal structure at 1.6 A resolution of an immunogenic, low-affinity peptide from the tumor-associated antigen MUC1, bound to H-2Kb. Stable binding is still achieved despite small, non-canonical residues in the C and F anchor pockets. This structure reveals how low-affinity peptides can be utilized in the design of novel peptide-based tumor vaccines. The molecular interactions elucidated in this non-canonical low-affinity peptide MHC complex should help uncover additional immunogenic peptides from primary protein sequences and aid in the design of alternative approaches for T-cell vaccines.
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The line below this paragraph, {{ABSTRACT_PUBMED_12083518}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12083518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12083518}}
==About this Structure==
==About this Structure==
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[[Category: Mucin]]
[[Category: Mucin]]
[[Category: Vntr]]
[[Category: Vntr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:14:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:50:39 2008''

Revision as of 01:50, 1 July 2008

Image:1g7q.png

Template:STRUCTURE 1g7q

CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND MUC1 VNTR PEPTIDE SAPDTRPA

Template:ABSTRACT PUBMED 12083518

About this Structure

1G7Q is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design., Apostolopoulos V, Yu M, Corper AL, Teyton L, Pietersz GA, McKenzie IF, Wilson IA, Plebanski M, J Mol Biol. 2002 May 17;318(5):1293-305. PMID:12083518

Page seeded by OCA on Tue Jul 1 04:50:39 2008

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