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1g99

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{{STRUCTURE_1g99| PDB=1g99 | SCENE= }}
{{STRUCTURE_1g99| PDB=1g99 | SCENE= }}
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'''AN ANCIENT ENZYME: ACETATE KINASE FROM METHANOSARCINA THERMOPHILA'''
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===AN ANCIENT ENZYME: ACETATE KINASE FROM METHANOSARCINA THERMOPHILA===
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==Overview==
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Acetate kinase, an enzyme widely distributed in the Bacteria and Archaea domains, catalyzes the phosphorylation of acetate. We have determined the three-dimensional structure of Methanosarcina thermophila acetate kinase bound to ADP through crystallography. As we previously predicted, acetate kinase contains a core fold that is topologically identical to that of the ADP-binding domains of glycerol kinase, hexokinase, the 70-kDa heat shock cognate (Hsc70), and actin. Numerous charged active-site residues are conserved within acetate kinases, but few are conserved within the phosphotransferase superfamily. The identity of the points of insertion of polypeptide segments into the core fold of the superfamily members indicates that the insertions existed in the common ancestor of the phosphotransferases. Another remarkable shared feature is the unusual, epsilon conformation of the residue that directly precedes a conserved glycine residue (Gly-331 in acetate kinase) that binds the alpha-phosphate of ADP. Structural, biochemical, and geochemical considerations indicate that an acetate kinase may be the ancestral enzyme of the ASKHA (acetate and sugar kinases/Hsc70/actin) superfamily of phosphotransferases.
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(as it appears on PubMed at http://www.pubmed.gov), where 11133963 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11133963}}
==About this Structure==
==About this Structure==
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[[Category: Hsc70]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:18:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:55:58 2008''

Revision as of 01:56, 1 July 2008

Image:1g99.png

Template:STRUCTURE 1g99

AN ANCIENT ENZYME: ACETATE KINASE FROM METHANOSARCINA THERMOPHILA

Template:ABSTRACT PUBMED 11133963

About this Structure

1G99 is a Single protein structure of sequence from Methanosarcina thermophila. Full crystallographic information is available from OCA.

Reference

Urkinase: structure of acetate kinase, a member of the ASKHA superfamily of phosphotransferases., Buss KA, Cooper DR, Ingram-Smith C, Ferry JG, Sanders DA, Hasson MS, J Bacteriol. 2001 Jan;183(2):680-6. PMID:11133963

Page seeded by OCA on Tue Jul 1 04:55:58 2008

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