1g9v

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{{STRUCTURE_1g9v| PDB=1g9v | SCENE= }}
{{STRUCTURE_1g9v| PDB=1g9v | SCENE= }}
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'''HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR'''
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===HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR===
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==Overview==
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The crystal structure of human deoxy hemoglobin (Hb) complexed with a potent allosteric effector (2-[4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid) = RSR-13) is reported at 1.85 A resolution. Analysis of the hemoglobin:effector complex indicates that two of these molecules bind to the central water cavity of deoxy Hb in a symmetrical fashion, and that each constrains the protein by engaging in hydrogen bonding and hydrophobic interactions with three of its four subunits. Interestingly, we also find that water-mediated interactions between the bound effectors and the protein make significant contributions to the overall binding. Physiologically, the interaction of RSR-13 with Hb results in increased oxygen delivery to peripheral tissues. Thus, this compound has potential therapeutic application in the treatment of hypoxia, ischemia, and trauma-related blood loss. Currently, RSR-13 is in phase III clinical trials as a radiosensitizing agent in the treatment of brain tumors. A detailed structural analysis of this compound complexed with deoxy Hb has important implications for the rational design of future analogs.
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The line below this paragraph, {{ABSTRACT_PUBMED_11316875}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11316875 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11316875}}
==About this Structure==
==About this Structure==
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[[Category: Hemoglobin tetramer]]
[[Category: Hemoglobin tetramer]]
[[Category: T state]]
[[Category: T state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:19:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:57:49 2008''

Revision as of 01:57, 1 July 2008

Image:1g9v.png

Template:STRUCTURE 1g9v

HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR

Template:ABSTRACT PUBMED 11316875

About this Structure

1G9V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector., Safo MK, Moure CM, Burnett JC, Joshi GS, Abraham DJ, Protein Sci. 2001 May;10(5):951-7. PMID:11316875

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