1ga5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ga5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ga5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ga5| PDB=1ga5 | SCENE= }}
{{STRUCTURE_1ga5| PDB=1ga5 | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT'''
+
===CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT===
-
==Overview==
+
<!--
-
Most nuclear receptors recognize the same consensus hexameric sequence, AGGTCA. An important question has been how the various members of this transcription factor family distinguish identity features in these closely related DNA sites. We determined structures from several crystal forms of the RevErb-DNA complex and analyzed the patterns of protein-DNA interactions and DNA distortions. We found a significant and consistent DNA distortion at a TA step directly preceding the first consensus 5'-AGGTCA-3' recognition sequence. Importantly, while this base-pair sequence is associated with RevErb's high-affinity sites, there are no sequence-specific contacts formed with the protein. Our study shows that RevErb relies instead on the intrinsic geometry and flexibility of this TA site to make the required fit between the proteins' independent major groove and minor groove binding interactions, which occur on both sides of the TA step. Our findings extend the description of response element discrimination to include a role for sequence-dependent DNA deformations and suggest how other monomeric members of this superfamily, such as NGFI-B, SF-1, and ROR, could also recognize unique geometric features in their DNA targets.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11669620}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11669620 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11669620}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Rev-erb]]
[[Category: Rev-erb]]
[[Category: Reverb]]
[[Category: Reverb]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:20:23 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:58:44 2008''

Revision as of 01:58, 1 July 2008

Image:1ga5.png

Template:STRUCTURE 1ga5

CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT

Template:ABSTRACT PUBMED 11669620

About this Structure

1GA5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

DNA deformability as a recognition feature in the reverb response element., Sierk ML, Zhao Q, Rastinejad F, Biochemistry. 2001 Oct 30;40(43):12833-43. PMID:11669620

Page seeded by OCA on Tue Jul 1 04:58:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ga5"
Personal tools