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1ga7

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{{STRUCTURE_1ga7| PDB=1ga7 | SCENE= }}
{{STRUCTURE_1ga7| PDB=1ga7 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE ADP-RIBOSE PYROPHOSPHATASE IN COMPLEX WITH GD+3'''
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===CRYSTAL STRUCTURE OF THE ADP-RIBOSE PYROPHOSPHATASE IN COMPLEX WITH GD+3===
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==Overview==
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Regulation of cellular levels of ADP-ribose is important in preventing nonenzymatic ADP-ribosylation of proteins. The Escherichia coli ADP-ribose pyrophosphatase, a Nudix enzyme, catalyzes the hydrolysis of ADP-ribose to ribose-5-P and AMP, compounds that can be recycled as part of nucleotide metabolism. The structures of the apo enzyme, the active enzyme and the complex with ADP-ribose were determined to 1.9 A, 2.7 A and 2.3 A, respectively. The structures reveal a symmetric homodimer with two equivalent catalytic sites, each formed by residues of both monomers, requiring dimerization through domain swapping for substrate recognition and catalytic activity. The structures also suggest a role for the residues conserved in each Nudix subfamily. The Nudix motif residues, folded as a loop-helix-loop tailored for pyrophosphate hydrolysis, compose the catalytic center; residues conferring substrate specificity occur in regions of the sequence removed from the Nudix motif. This segregation of catalytic and recognition roles provides versatility to the Nudix family.
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The line below this paragraph, {{ABSTRACT_PUBMED_11323725}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11323725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11323725}}
==About this Structure==
==About this Structure==
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[[Category: Mg binding]]
[[Category: Mg binding]]
[[Category: Nudix hydrolase]]
[[Category: Nudix hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:20:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:58:53 2008''

Revision as of 01:58, 1 July 2008

Image:1ga7.png

Template:STRUCTURE 1ga7

CRYSTAL STRUCTURE OF THE ADP-RIBOSE PYROPHOSPHATASE IN COMPLEX WITH GD+3

Template:ABSTRACT PUBMED 11323725

About this Structure

1GA7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family., Gabelli SB, Bianchet MA, Bessman MJ, Amzel LM, Nat Struct Biol. 2001 May;8(5):467-72. PMID:11323725

Page seeded by OCA on Tue Jul 1 04:58:53 2008

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