1gak

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{{STRUCTURE_1gak| PDB=1gak | SCENE= }}
{{STRUCTURE_1gak| PDB=1gak | SCENE= }}
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'''CRYSTAL STRUCTURE OF GREEN ABALONE SP18'''
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===CRYSTAL STRUCTURE OF GREEN ABALONE SP18===
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==Overview==
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Sp18 is an 18 kDa protein that is released from abalone sperm during the acrosome reaction. It coats the acrosomal process where it is thought to mediate fusion between sperm and egg cell membranes. Sp18 is evolutionarily related to lysin, a 16 kDa abalone sperm protein that dissolves the vitelline envelope surrounding the egg. The two proteins were generated by gene duplication followed by rapid divergence by positive selection. Here, we present the crystal structure of green abalone sp18 resolved to 1.86 A. Sp18 is composed of a bundle of five alpha-helices with surface clusters of basic and hydrophobic residues, giving it a large dipole moment and making it extremely amphipathic. The large clusters of hydrophobic surface residues and domains of high positive electrostatic surface charge explain sp18's ability as a potent fusagen of liposomes. The overall fold of sp18 is similar to that of green abalone lysin; however, the surface features of the proteins are quite different, accounting for their different roles in fertilization. This is the first crystal structure of a protein implicated in sperm-egg fusion during animal fertilization.
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The line below this paragraph, {{ABSTRACT_PUBMED_11331004}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11331004 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11331004}}
==About this Structure==
==About this Structure==
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[[Category: Vacquier, V D.]]
[[Category: Vacquier, V D.]]
[[Category: Helical bundle]]
[[Category: Helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:21:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:59:54 2008''

Revision as of 01:59, 1 July 2008

Image:1gak.png

Template:STRUCTURE 1gak

CRYSTAL STRUCTURE OF GREEN ABALONE SP18

Template:ABSTRACT PUBMED 11331004

About this Structure

1GAK is a Single protein structure of sequence from Haliotis fulgens. Full crystallographic information is available from OCA.

Reference

The crystal structure of a fusagenic sperm protein reveals extreme surface properties., Kresge N, Vacquier VD, Stout CD, Biochemistry. 2001 May 8;40(18):5407-13. PMID:11331004

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