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1gcm

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[[Image:1gcm.gif|left|200px]]
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{{STRUCTURE_1gcm| PDB=1gcm | SCENE= }}
{{STRUCTURE_1gcm| PDB=1gcm | SCENE= }}
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'''GCN4 LEUCINE ZIPPER CORE MUTANT P-LI'''
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===GCN4 LEUCINE ZIPPER CORE MUTANT P-LI===
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==Overview==
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Subunit oligomerization in many proteins is mediated by short coiled-coil motifs. These motifs share a characteristic seven-amino-acid repeat containing hydrophobic residues at the first (a) and fourth (d) positions. Despite this common pattern, different sequences form two-, three- and four-stranded helical ropes. We have investigated the basis for oligomer choice by characterizing variants of the GCN4 leucine-zipper dimerization domain that adopt trimeric or tetrameric structures in response to mutations at the a and d positions. We now report the high-resolution X-ray crystal structure of an isoleucine-containing mutant that folds into a parallel three-stranded, alpha-helical coiled coil. In contrast to the dimer and tetramer structures, the interior packing of the trimer can accommodate beta-branched residues in the most preferred rotamer at both hydrophobic positions. Compatibility of the shape of the core amino acids with the distinct packing spaces in the two-, three- and four-stranded conformations appears to determine the oligomerization state of the GCN4 leucine-zipper variants.
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The line below this paragraph, {{ABSTRACT_PUBMED_8072533}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8072533 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8072533}}
==About this Structure==
==About this Structure==
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[[Category: Kim, P S.]]
[[Category: Kim, P S.]]
[[Category: Hydrophobic core mutant]]
[[Category: Hydrophobic core mutant]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:25:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:05:12 2008''

Revision as of 02:05, 1 July 2008

Image:1gcm.png

Template:STRUCTURE 1gcm

GCN4 LEUCINE ZIPPER CORE MUTANT P-LI

Template:ABSTRACT PUBMED 8072533

About this Structure

1GCM is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of an isoleucine-zipper trimer., Harbury PB, Kim PS, Alber T, Nature. 1994 Sep 1;371(6492):80-3. PMID:8072533

Page seeded by OCA on Tue Jul 1 05:05:12 2008

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