1gd5

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{{STRUCTURE_1gd5| PDB=1gd5 | SCENE= }}
{{STRUCTURE_1gd5| PDB=1gd5 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE'''
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===SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE===
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==Overview==
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The phox homology (PX) domain is a novel protein module containing a conserved proline-rich motif. We have shown that the PX domain isolated from the human p47phox protein, a soluble subunit of phagocyte NADPH oxidase, binds specifically to the C-terminal SH3 domain derived from the same protein. The solution structure of p47 PX has an alpha + beta structure with a novel folding motif topology and reveals that the proline-rich motif is presented on the molecular surface for easy recognition by the SH3 domain. The proline-rich motif of p47 PX in the free state adopts a distorted left-handed polyproline type II helix conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 11373621 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11373621}}
==About this Structure==
==About this Structure==
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1GD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD5 OCA].
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1GD5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GD5 OCA].
==Reference==
==Reference==
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[[Category: Sumimoto, H.]]
[[Category: Sumimoto, H.]]
[[Category: Alpha beta,p47-phox,px domain]]
[[Category: Alpha beta,p47-phox,px domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:26:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:07:21 2008''

Revision as of 02:07, 1 July 2008

Image:1gd5.png

Template:STRUCTURE 1gd5

SOLUTION STRUCTURE OF THE PX DOMAIN FROM HUMAN P47PHOX NADPH OXIDASE

Template:ABSTRACT PUBMED 11373621

About this Structure

1GD5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the PX domain, a target of the SH3 domain., Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D, Nat Struct Biol. 2001 Jun;8(6):526-30. PMID:11373621

Page seeded by OCA on Tue Jul 1 05:07:21 2008

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