1ggi

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{{STRUCTURE_1ggi| PDB=1ggi | SCENE= }}
{{STRUCTURE_1ggi| PDB=1ggi | SCENE= }}
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'''CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN'''
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===CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN===
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==Overview==
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The crystal structure of the Fab fragment of a human immunodeficiency virus type 1 (HIV-1) neutralizing monoclonal antibody Fab has been determined at 2.8 A resolution in complex with a linear 16-residue peptide from the third hypervariable region (V3) of gp120. The first 9 residues of the peptide are ordered in the electron density maps, and their conformation is in partial agreement with the beta-strand-type II beta-turn structure predicted for this portion of the V3 loop. Notably, several of the peptide residues that are well conserved among different HIV-1 isolates contact a nonpolar 25-A-long groove in the antibody-combining site. The largely extended structure of the peptide differs from the beta-turns seen as the primary determinants in other published anti-peptide Fab structures. Analysis of the specific Fab-peptide interactions only partially explains the MN isolate specificity shown by this antibody.
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The line below this paragraph, {{ABSTRACT_PUBMED_8327513}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8327513 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8327513}}
==About this Structure==
==About this Structure==
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:31:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:14:59 2008''

Revision as of 02:15, 1 July 2008

Image:1ggi.png

Template:STRUCTURE 1ggi

CRYSTAL STRUCTURE OF AN HIV-1 NEUTRALIZING ANTIBODY 50.1 IN COMPLEX WITH ITS V3 LOOP PEPTIDE ANTIGEN

Template:ABSTRACT PUBMED 8327513

About this Structure

1GGI is a Protein complex structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen., Rini JM, Stanfield RL, Stura EA, Salinas PA, Profy AT, Wilson IA, Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6325-9. PMID:8327513

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