1ggt

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[[Image:1ggt.gif|left|200px]]
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{{STRUCTURE_1ggt| PDB=1ggt | SCENE= }}
{{STRUCTURE_1ggt| PDB=1ggt | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII'''
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===THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII===
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==Overview==
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Mechanical stability in many biological materials is provided by the crosslinking of large structural proteins with gamma-glutamyl-epsilon-lysyl amide bonds. The three-dimensional structure of human recombinant factor XIII (EC 2.3.2.13 zymogen; protein-glutamine:amine gamma-glutamyltransferase a chain), a transglutaminase zymogen, has been solved at 2.8-A resolution by x-ray crystallography. This structure shows that each chain of the homodimeric protein is folded into four sequential domains. A catalytic triad reminiscent of that observed in cysteine proteases has been identified in the core domain. The amino-terminal activation peptide of each subunit crosses the dimer interface and partially occludes the opening of the catalytic cavity in the second subunit, preventing substrate binding to the zymogen. A proposal for the mechanism of activation by thrombin and calcium is made that details the structural events leading to active factor XIIIa'.
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The line below this paragraph, {{ABSTRACT_PUBMED_7913750}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7913750 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7913750}}
==About this Structure==
==About this Structure==
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[[Category: Yee, V C.]]
[[Category: Yee, V C.]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:32:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:15:49 2008''

Revision as of 02:15, 1 July 2008

Image:1ggt.png

Template:STRUCTURE 1ggt

THREE-DIMENSIONAL STRUCTURE OF A TRANSGLUTAMINASE: HUMAN BLOOD COAGULATION FACTOR XIII

Template:ABSTRACT PUBMED 7913750

About this Structure

1GGT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII., Yee VC, Pedersen LC, Le Trong I, Bishop PD, Stenkamp RE, Teller DC, Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7296-300. PMID:7913750

Page seeded by OCA on Tue Jul 1 05:15:49 2008

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