1ggz

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{{STRUCTURE_1ggz| PDB=1ggz | SCENE= }}
{{STRUCTURE_1ggz| PDB=1ggz | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS'''
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===CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS===
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==Overview==
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A calmodulin (CaM)-like protein (hCLP) is expressed in human mammary epithelial cells but appears to be limited to certain epithelial cells such as those found in skin, prostate, breast and cervical tissues. A decrease in the expression of this protein is associated with the occurrence of tumors in breast epithelium. The structure of hCLP determined to 1.5 A resolution by X-ray crystallography shows a distinct 30 degrees displacement along the interconnecting central helix, when compared to the highly conserved structure of vertebrate CaM, resulting in a difference in the relative orientation of its two globular domains. Additionally, the electric surface potential landscape at the target protein binding regions on the two globular domains of hCLP is significantly different from those of CaM, indicating that the respective ranges of hCLP and hCaM target proteins do not fully overlap. Observations that hCLP can competitively inhibit CaM activation of target proteins also imply a role for hCLP in which it may also serve as a modulator of CaM activity in the epithelial cells where hCLP is expressed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12067719 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12067719}}
==About this Structure==
==About this Structure==
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[[Category: Ca+2 binding protein]]
[[Category: Ca+2 binding protein]]
[[Category: Ef hand]]
[[Category: Ef hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:32:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:16:20 2008''

Revision as of 02:16, 1 July 2008

Image:1ggz.png

Template:STRUCTURE 1ggz

CRYSTAL STRUCTURE OF THE CALMODULIN-LIKE PROTEIN (HCLP) FROM HUMAN EPITHELIAL CELLS

Template:ABSTRACT PUBMED 12067719

About this Structure

1GGZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human calmodulin-like protein: insights into its functional role., Han BG, Han M, Sui H, Yaswen P, Walian PJ, Jap BK, FEBS Lett. 2002 Jun 19;521(1-3):24-30. PMID:12067719

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