1gh2

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{{STRUCTURE_1gh2| PDB=1gh2 | SCENE= }}
{{STRUCTURE_1gh2| PDB=1gh2 | SCENE= }}
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'''Crystal structure of the catalytic domain of a new human thioredoxin-like protein'''
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===Crystal structure of the catalytic domain of a new human thioredoxin-like protein===
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==Overview==
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Thioredoxin is a ubiquitous dithiol oxidoreductase found in many organisms and involved in numerous biochemical processes. Human thioredoxin-like protein (hTRXL) is differentially expressed at different development stages of human fetal cerebrum and belongs to an expanding family of thioredoxins. We have solved the crystal structure of the recombinant N-terminal catalytic domain (hTRXL-N) of hTRXL in its oxidized form at 2.2-A resolution. Although this domain shares a similar three-dimensional structure with human thioredoxin (hTRX), a unique feature of hTRXL-N is the large number of positively charged residues distributed around the active site, which has been implicated in substrate specificity. Furthermore, the hTRXL-N crystal structure is monomeric while hTRX is dimeric in its four crystal structures (reduced, oxidized, C73S and C32S/C35S mutants) reported to date. As dimerization is the key regulatory factor in hTRX, the positive charge and lack of dimer formation of hTRXL-N suggest that it could interact with the acidic amino-acid rich C-terminal region, thereby suggesting a novel regulation mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 11985582 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11985582}}
==About this Structure==
==About this Structure==
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[[Category: Yuan, J.]]
[[Category: Yuan, J.]]
[[Category: Redox-active center]]
[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:33:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:16:32 2008''

Revision as of 02:16, 1 July 2008

Image:1gh2.png

Template:STRUCTURE 1gh2

Crystal structure of the catalytic domain of a new human thioredoxin-like protein

Template:ABSTRACT PUBMED 11985582

About this Structure

1GH2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of a human thioredoxin-like protein., Jin J, Chen X, Zhou Y, Bartlam M, Guo Q, Liu Y, Sun Y, Gao Y, Ye S, Li G, Rao Z, Qiang B, Yuan J, Eur J Biochem. 2002 Apr;269(8):2060-8. PMID:11985582

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