1ghh

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{{STRUCTURE_1ghh| PDB=1ghh | SCENE= }}
{{STRUCTURE_1ghh| PDB=1ghh | SCENE= }}
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'''SOLUTION STRUCTURE OF DINI'''
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===SOLUTION STRUCTURE OF DINI===
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==Overview==
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The Escherichia coli RecA protein triggers both DNA repair and mutagenesis in a process known as the SOS response. The 81-residue E. coli protein DinI inhibits activity of RecA in vivo. The solution structure of DinI has been determined by multidimensional triple resonance NMR spectroscopy, using restraints derived from two sets of residual dipolar couplings, obtained in bicelle and phage media, supplemented with J couplings and a moderate number of NOE restraints. DinI has an alpha/beta fold comprised of a three-stranded beta-sheet and two alpha-helices. The beta-sheet topology is unusual: the central strand is flanked by a parallel and an antiparallel strand and the sheet is remarkably flat. The structure of DinI shows that six negatively charged Glu and Asp residues on DinI's kinked C-terminal alpha-helix form an extended, negatively charged ridge. We propose that this ridge mimics the electrostatic character of the DNA phospodiester backbone, thereby enabling DinI to compete with single-stranded DNA for RecA binding. Biochemical data confirm that DinI is able to displace ssDNA from RecA.
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The line below this paragraph, {{ABSTRACT_PUBMED_11152126}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11152126 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11152126}}
==About this Structure==
==About this Structure==
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1GHH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1f0a 1f0a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GHH OCA].
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1GHH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1f0a 1f0a]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GHH OCA].
==Reference==
==Reference==
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[[Category: Pf1]]
[[Category: Pf1]]
[[Category: Reca]]
[[Category: Reca]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:17:40 2008''

Revision as of 02:17, 1 July 2008

Image:1ghh.png

Template:STRUCTURE 1ghh

SOLUTION STRUCTURE OF DINI

Template:ABSTRACT PUBMED 11152126

About this Structure

1GHH is a Single protein structure of sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1f0a. Full experimental information is available from OCA.

Reference

Solution structure of DinI provides insight into its mode of RecA inactivation., Ramirez BE, Voloshin ON, Camerini-Otero RD, Bax A, Protein Sci. 2000 Nov;9(11):2161-9. PMID:11152126

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